The Clinically Proven Laxative
Ramkumar D., Am J Gastroenterol. 2005;100:936-71
The active ingredient in Relaxa™
Relaxa™ Prescribing Information, Red Leaf Medical Inc., 2010

A number of published studies have been performed to investigate the efficacy and safety of polyethylene glycol for constipation.

Reference 1
Efficacy and safety of traditional medical therapies for chronic constipation: systematic review.
Rankumar D, Rao SS. Am J Gastroenterol. 2005 Apr; 100(4):936-71.

Other Clinical Evidence
A Randomized, Multicenter, Placebo-Controlled Trial of Polyethylene Glycol Laxative for Chronic Treatment of Chronic Constipation
Jack A. DiPalma, M.D., F.A.C.G., Mark vB. Cleveland, Ph.D., John McGowan, B.S.,
and Jorge L. Herrera, M.D., F.A.C.G. Am J Gastroenterol 2007;102:1436–1441.

Lactulose versus Polyethylene Glycol for Chronic Constipation.
Lee-Robichaud H, Thomas K. Morgan J, Nelson RL. Cochrane Database Syst Rev. 2010 Jul 7: (7):CD007570.

PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial.
Voskuijl W, de Lorijn F, Verwijs W, Hogeman P, Heijmans J, Mäkel W, Taminiau J, Benninga M. Gut. 2004 Nov;53(11):1590-4.

Recommendations on chronic constipation (including constipation associated with irritable bowel syndrome) treatment.
Paré P, Bridges R, Champion MC, Ganguli SC, Gray JR, Irvine EJ, Plourde V, Poitras P, Turnbull GK, Moayyedi P, Flook N, Collins SM, Can J Gastroenterol. 2007 Apr: 21 Suppl B:3B-22B.

Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers.
Loening-Baucke V, Krishna R, Pashankar DS.  J Pediatr Gastroenterol Nutr. 2004 Nov; 39(5):536-9.

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